Long-term Potentiation Enhancing Neuroscience for 30 Years

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Format: Hardcover
Pub. Date: 2004-05-27
Publisher(s): Oxford University Press
List Price: $195.99

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Summary

In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP isthought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actualneural mechanism used by the brain to store information? This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research thatcover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today. Advance praise for Long Term Potentiation: "This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field." Colin Blakemore, University of Oxford

Table of Contents

List of Contributors
xi
Introduction
xv
T. V. P. Bliss
G. L. Collingridge
R. G. M. Morris
HISTORY
A prelude to long-term potentiation
3(6)
P. Andersen
The discovery of long-term potentiation
9(8)
T. Lømo
A journey from neocortex to hippocampus
17(6)
T. V. P. Bliss
Long-term potentiation in the Eocene
23(8)
G. Lynch
Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history
31(10)
B. L. McNaughton
The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation
41(12)
G. L. Collingridge
Long-term potentiation and memory
53(12)
R. G. M. Morris
INDUCTION
Bidirectional synaptic plasticity: from theory to reality
65(14)
M. F. Bear
Kainate receptors and the induction of mossy fibre long-term potentiation
79(16)
Z. A. Bortolotto
S. Lauri
J. T. R. Isaac
G. L. Collingridge
Active dendrites, potassium channels, and synaptic plasticity
95(16)
D. Johnston
B. R. Christie
A. Frick
R. Gray
D. A. Hoffman
L. K. Schexnayder
S. Watanabe
L.-L. Yuan
EXPRESSION
Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode
111(22)
M. L. Errington
P. T. Galley
T. V. P. Bliss
Imaging spatio-temporal patterns of long-term potentiation in mouse hippocampus
133(8)
T. Hosokawa
M. Ohta
T. Saito
A. Fine
Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation
141(18)
S. Choi
J. Klingauf
R. W. Tsien
AMPA receptor trafficking and long-term potentiation
159(16)
R. Malinow
GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity
175(10)
F. Duprat
M. Daw
W. Lim
G. Collingridge
J. Isaac
Expression mechanisms underlying long-term potentiation: a postsynaptic view
185(12)
R. A. Nicoll
Silent synapses: what are they telling us about long-term potentiation?
197(14)
D. M. Kullmann
PERSISTENCE
How long will long-term potentiation last?
211(18)
W. C. Abraham
Structural changes at dendritic spine synapses during long-term potentiation
229(6)
K. M. Harris
J. C. Fiala
L. Ostroff
Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic β-catenin-cadherin interactions
235(14)
E. M. Schuman
S. Murase
In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus
249(14)
C. Pittenger
E. R. Kandel
FUNCTION
Long-term potentiation and the ageing brain
263(14)
C. A. Barnes
Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory
277(24)
R. G. M. Morris
E. I. Moser
G. Riedel
S. J. Martin
J. Sandin
M. Day
C. O'Carroll
Genetic neuroscience of mammalian learning and memory
301(14)
S. Tonegawa
K. Nakazawa
M. A. Wilson
Inducible molecular switches for the study of long-term potentiation
315(14)
G. Hedou
I. M. Mansuy
MAPK, CREB, and zif268 are all required for the consolidation of recognition memory
329(20)
B. Bozon
A. Kelly
S. A. Josselyn
A. J. Silva
S. Davis
S. Laroche
NEW DIRECTIONS
Synaptic plasticity in the mesolimbic dopamine system
349(8)
M. J. Thomas
R. C. Malenka
Synaptic plasticity in animal models of early Alzheimer's disease
357(14)
M. J. Rowan
I. Klyubin
W. K. Cullen
R. Anwyl
Long-term potentiation: outstanding questions and attempted synthesis
371(22)
J. Lisman
Index 393

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